Table 3.

Six protein markers across different clinical states

Analyte	NC (n=148) (Mean±SD)	SCD (n=138) (Mean±SD)	aMCI (n=74) (Mean±SD)	AD (n=43) (Mean±SD)	P value SCD vs NC	P value aMCI vs NC	P value AD vs NC
ApoA1 (ng/ml)	32.07±17.13	33.63±16.47	34.02±14.39	33.81±17.83	NS	NS	NS
ApoCIII (ng/ml)	25.22±11.87	26.68±11.43	28.19±10.77	28.55±12.46	NS	0.013	NS
ApoE (ng/ml)	7.30±3.75	7.26±3.33	7.97±3.18	7.05±2.80	NS	0.026	NS
A2M (ng/ml)	114.69±54.82	114.83±52.88	137.10±55.18	121.51±47.93	NS	0.003	NS
C3 (ng/ml)	0.96±0.64	1.00±0.70	1.25±0.69	1.20±0.64	NS	＜0.001	0.007
FH (ng/ml)	23.42±9.29	23.37±10.28	25.67±8.28	22.55±6.24	NS	0.035	NS

All data are expressed as mean±SD. Multiple linear regression with age, sex, APOE genotype and education level used as covariates.

AD, Alzheimer’s disease; A2M, A-2-macroglobulin; aMCI, amnestic mild cognitive impairment; ApoA1, apolipoprotein A1; ApoCIII, apolipoprotein CIII; ApoE, apolipoprotein E; C3, complement C3; FH, complement factor H; NC, normal controls; SCD, subjective cognitive decline.