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. 2022 Mar;10(5):249. doi: 10.21037/atm-21-5837

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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TRPC6 markedly enhanced viability and resisted necrosis in OGD/R HK-2 cells. HK-2 cells were first induced with OGD/R, and then transfected with sh-TRPC6 and OE-TRPC6, respectively. (A) MTT exhibited the change in viability; (B) flow cytometry displayed the change in the degree of cell necrosis; (C) Western blot presented the changes in Sirtuin-2, RIP1, and PARP-1 expressions, and the relative quantification was confirmed. *, P<0.05; **, P<0.01; ***, P<0.001. MTT, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide.