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. 2022 Mar;10(5):249. doi: 10.21037/atm-21-5837

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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TRPC6 promoted Zn²⁺ influx and autophagy in OGD/R HK-2 cells by accelerating Zn²⁺ influx and autophagy. OGD/R HK-2 cells were co-processed as shown in Figure 6. (A) The change of free Zn²⁺ was confirmed with a Zn²⁺ fluorescent probe; (B) Western blotting analysis of autophagy-associated proteins. *, P<0.05; **, P<0.01; ***, P<0.001.