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. 2022 Mar;10(5):262. doi: 10.21037/atm-22-407

Figure 3.

Figure 3

Metabolic heterogeneity of CAFs. (A) Heatmap showing altered metabolic pathways in CAF subtypes; (B) enrichment score of the top 6 most altered metabolic pathways (****, P<0.0001); (C) Dot plot showing the different correlation between CAF subtypes and metabolic pathways using Pearson correlation algorithm. CAFs, cancer-associated fibroblasts. ns, not significant. ES, enrichment score; MPES, metabolic pathway enrichment score. myCAF, myofibroblastic CAF; iCAF, inflammatory CAF; apCAF, antigen-presenting CAF.