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. 2022 Mar;10(5):262. doi: 10.21037/atm-22-407

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2022 Annals of Translational Medicine. All rights reserved.

Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0.

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Distinct transcriptional activity and gene regulatory networks of CAF subtypes. (A,B) SCENIC (A) and Seurat (B) dimension reduction algorithms reveal similar CAF subgroups; (C) heatmap showing the regulon activity of CAF subtypes; (D) regulon specificity score of the regulon activity of CAF subtypes. CAF, cancer-associated fibroblast. RSS, regulon specificity score. iCAF, inflammatory cancer-associated fibroblast; myCAF, myofibroblast cancer-associated fibroblast; apCAF, antigen-presenting CAF.