FIGURE 3.

Correlation between in vitro affinity of antipsychotics for human D₂Rs and D₃Rs (A, data taken from Table 1; various radioligands) and for rat striatal D₂Rs (striatal membrane) and cerebellar D₃Rs (CB L9,10 membrane) (B); rat D₂R and D₃R affinity data derive from the extension of the study of Kiss et al. (81) and Kiss et al. (82). Determination of D₂R and D₃R affinity in membranes from CHO cells expressing human D₃R or cerebellar L9,10 membranes (ligand: [³H]-(+)-PHNO) is described in Kiss et al. (81).