FIGURE 5.

Graphical presentation of percent changes in striatal dopamine turnover indices (DATI) at D₃R (i.e., cerebellar L9, 10) occupancy ED₅₀ doses (A) and at D₂R (i.e., striatal) occupancy ED₅₀ doses (B) in vivo^*,#. *Doses in brackets denote the occupancy ED₅₀ doses (or close to ED₅₀) taken from Table 2. Dopamine turnover index (DATI) was estimated from turnover dose-response curves (consisting of at least 4–5 doses, with five rats in each dose-group) for individual compounds listed in this figure. In cases where the occupancy ED₅₀ values could not be exactly calculated (see Table 2) the turnover indices were determined at doses denoted with asterisks. Dopamine turnover index was defined as DA/(DOPAC+HVA). Determination of tissue dopamine, DOPAC and HVA was carried out exactly as described in Kiss et al. (22) (for abbreviations of drugs’ names, see Table 2). ^#Dopamine turnover data for cariprazine and DD-CAR were published in Kiss et al. (173). Turnover results of other compounds are unpublished and are on file at G. Richter. Plc.