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. 2022 Mar 24;16:819569. doi: 10.3389/fnins.2022.819569

FIGURE 2.

FIGURE 2

Dox treatment induces progressive frataxin deficiency in the cerebellum of FRDAkd mice. (A) Western blot analysis of frataxin (FXN) and internal loading control (actin) levels in the cerebellum of WT and TG + mice at 4 weeks, 8–12 weeks, and 18 weeks of dox treatment. (B) Quantification of frataxin levels normalized to internal control actin. The frataxin expression levels are reported as a percentage of the wild type at each time point set to 100 percent (Stats: WT, n = 3, TG +, n = 3, mean ± SEM, two-tailed, unpaired Student’s t-test, **P < 0.01, ***P < 0.001).