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. 2022 Mar 24;16:819569. doi: 10.3389/fnins.2022.819569

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Copyright © 2022 Mercado-Ayón, Warren, Halawani, Rodden, Ngaba, Dong, Chang, Fonck, Mavilio, Lynch and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mitochondrial fission protein Drp1 is progressively overactivated in the cerebellum of FRDAkd mice. (A) Western blot analysis of pDRP1 (S616), Drp1, and internal loading control (actin) levels in cerebellum of WT and TG + mice at 4 weeks, 8–12 weeks, and 18 weeks of dox treatment. (B) Quantification (normalized to actin) of pDRP1 (top panel), Drp1 (middle panel), and pDrp1/Drp1 ratio (bottom panel) normalized to actin (Stats: WT, n = 3, TG + , n = 3, mean ± SEM, two-tailed, unpaired Student’s t-test, *P < 0.05, **P < 0.01, ***P < 0.001).