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FRDAkd mice show progressive glutamatergic and GABAergic synaptic deficits in the cerebellum. Western blot and quantification of VGLUT1, VGLUT2 (A,B), GAD65, and GAD67 (C,D) levels normalized to internal control actin in WT and TG + mice at 4 weeks, 8–12 weeks, and 18 weeks of dox treatment (Stats: WT, n = 3, TG +, n = 3, mean ± SEM, two-tailed, unpaired Student’s t-test, *P < 0.05, **P < 0.01).
