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. 2022 Mar 24;9:848450. doi: 10.3389/fnut.2022.848450

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Copyright © 2022 Nonaka, Ohue-Kitano, Masujima, Igarashi and Kimura.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Medium-chain triglyceride (MCT) administration enhances glucose tolerance. (A) Oral glucose tolerance test (OGTT) was performed at 1 h post-MCT administration (2.4 g/kg body weight) (n = 7). ^**P < 0.01; ^*P < 0.05 (Tukey-Kramer test). (B) The plasma levels of insulin (left; n = 8–10) and GLP-1 (right; n = 8–10) at 1.5 h after the oral administration of MCTs. ^**P < 0.01 vs. vehicle control (Dunnett's test). (C) and (D) Medium-chain fatty acid (MCFA) levels in ileal content (C) or tissue (D) of ileum at 1 h after the oral administration of MCTs (n = 10–12). The concentration of MCFAs were measured by liquid chromatography/mass spectrometry (LC/MS). TriC8, octanoate (C8:0) triglyceride; TriC10, decanoate (C10:0) triglyceride; TriC12, dodecanoate (C12:0) triglyceride.