Figure 5.

Decanoate (C10:0) enhanced glucose tolerance via GPR84-mediated GLP-1 secretion in mice. (A) Oral glucose tolerance test (OGTT) was performed at 1 h post-decanoate triglyceride administration (2.4 g/kg body weight) (left, WT mice; n = 7, 6; right, Gpr84^−/− mice; n = 5). (B) OGTT was performed at 2 h post-decanoate administration (1 g/kg body weight) (left, WT; right, Gpr84^−/− mice; n = 7). (C) The plasma levels of insulin (left) and GLP-1 (right) at 2.5 h after the oral administration of decanoate (n = 7). ^**P < 0.01, ^*P < 0.05 (Tukey-Kramer test). All data are presented as the means ± standard error of mean (SEM).