TABLE 1.
Proteins/genes, their impact on self-renewal, and their interaction with other proteins/genes involved in regulating hematopoiesis.
| Proteins/genes | Impact on self-renewal | Interacting proteins/genes | PMID |
|---|---|---|---|
| Angptl3 (Angiopoietin-like protein-3) | Increases | Ikaros | 20959605 |
| β−catenin | Increases | Notch1, HOXB4 | 18371452, 26344907 |
| Bmi-1 (B cell-specific moloney murine leukemia virus integration site 1) | Increases | p16Ink4a, p19Arf, Ezh1, Ezh2 | 16954369, 12714971 |
| Bmp4 (Bone morphogenetic protein 4) | Increases | p38 MAPK, MITF, ITGA4 | 23243277, 19759357 |
| C/EBPa (CCAAT enhancer binding protein-a) | Decreases | N-Myc | 23502316 |
| CaR (Calcium-sensing receptor) | Increases | — | 16382241 |
| Catalase | Increases | — | 25603016 |
| Cdh2 (Cadherin-2) | Increases | Ctnnb1 | 22901259, 20207221 |
| Cdkn1a or p21 (Cyclin dependent kinase inhibitor 1a) | Increases | Dkk1, NF-Y, Skp2, Ptpmt1, Gfi1, Egr1 | 10710306, 18397757, 15457180, 23290137, 21502543, 18371452, 22072554 |
| Cdkn1c or p57 (Cyclin dependent kinase inhibitor 1c) | Increases | p27, Ccnd2, Ccnd1, Cdk4, Cdk6 | 21885020, 21885021 |
| Cdkn2c or p18 (Cyclin dependent kinase inhibitor 2c) | Decreases | p21, p18 | 15122268 |
| c-Kit | Increases | Bcl-2, SCL and SCF, PI3K/MAPK | 18250409, 24446491, 1721869 |
| c-Mpl | Increases | TPO/JAK2 | 9448308, 18618018, 18371409 |
| c-Myb | Increases | PU.1, b-Myb | 24516162, 20823231, 19955420 |
| CREBBP/Cbp (CREB binding protein) | Increases | Ccnd1, Ccnd2, p21, Rb1, Mcm7, Gfi1b, Cxcl12 | 22006020 |
| Dmtf1 (Cyclin D binding Myb like transcription factor 1) | Decreases | p21, p57, Cdkn2a, Ccnd1, Junb, Cdk6 | 22039255 |
| Dkk1 (Dickkopf-1) | Decreases | Cdkn1a (p21Cip1) | 18371452 |
| Egr1 (Early growth response 1) | Increases | Bmi1, Cdk4, p21 | 18397757 |
| Erdr1 (Erythroid differentiation regulator 1) | Increases | Fos, Tcfec, Sfpi1, Hmgb | 19379700 |
| Erg (ETS-related gene) | Increases | c-Mpl/TPO | 21673349 |
| Evi-1 (Ecotropic viral integration site-1) | Increases | GATA-2, Pbx1, Runx1, TGF-β | 29658164, 12032771,24573248 |
| Ezh1 (Enhancer Of Zeste 1 Polycomb Repressive Complex 2 Subunit) | Increases | Cdkn2a, Bmi1, Igfbp3, IL-6, p21, Zmat3, Bmp2, p16Ink4a | 23122289 |
| Ezh2 (Enhancer of zeste 2 polycomb repressive complex 2 subunit) | Increases | HOX isoforms | 16293602 |
| FoxO3 | Increases | Cdkn1b, p57, Catalase | 18371339 |
| GATA-3 | Increases and decreases | p38 MAPK, GFI1, MEF/ELF4, FoxO3A, GFI1B, EGR1, JUNB | 19377048, 22267605, 23974957 |
| Gfi1 (Growth factor independent 1 transcriptional repressor) | Increases | Mysm1, GATA-2, p21, RUNX1 | 15457180 |
| Hes1 (Hairy and enhancer of split 1) | Increases | RBP, Notch1 | 12406868 |
| HIF-1α (Hypoxia inducible factor 1α) | Increases | p16Ink4a/p19(Arf) | 20804974 |
| HOXB4 (Homeobox B4) | Increases | — | 7622039 |
| IGFBP2 (Insulin Like growth factor binding protein 2) | Increases | Cdkn2a, PTEN, p19, p57, p21, p16 | 21821709 |
| Ikzf1 | Decreases | Hes1 | 20959605 |
| Itch (Itchy E3 ubiquitin protein ligase) | Decreases | Notch1 | 21478879 |
| Jagged-1 | Increases | Vcam, Hes1, Hey1, Notch | 24012753 |
| Keap (Kelch Like ECH associated protein 1) | Increases | Nrf2 | 28674188 |
| Klf10 (Kruppel Like Factor 10) | Increases | Fos, Tcfec, Sfpi1, Hmgb | 19379700 |
| Meis1 | Increases | HIF-1α, Pbx1 | 23091297 |
| MK2 or MAPKAPK2 (MAPK Activated Protein kinase 2) | Increases | Edr1/2, Phc1, Phc2 | 19369945 |
| NF-Ya (Nuclear transcription factor Y-α) | Increases | Notch1, Hes1, p21, Bmi1, Bcl-2, HOX4, LEF-1 | 22072554, 16081537 |
| Notch1 | Increases | Satb1, Jagged-1, Itch | 16151515, 21478879, 11895769 |
| Nrf2 (Nuclear factor erythroid 2-related factor 2) | Increases | CXCL12/CXCR4, Ccnd1, PI3K/Akt | 23434824 |
| p38 MAPK | Decreases | Ask1, Cdkn2a | 16565722 |
| Pbx-1 | Increases | P21 and p57, TGF-β, MAPK | 24573248 |
| Pcgf2 (Polycomb group ring finger 2) | Decreases | HOXB4 | 15183898 |
| Pdk2, Pdk4 (Pyruvate dehydrogenase kinase) | Increases | HIF-1α | 23290136 |
| Pld3 (phospholipase D family member 3) | Increases | — | 19377048 |
| Prnp (Prion Protein) | Increases | — | 19377048 |
| PTEN (phosphatase and TENsin homolog deleted on chromosome 10) | Increases | Skp2, mTOR | 21931116, 16598206 |
| Ptpmt1 (phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1) | Increases | p21, p57) | 23290137 |
| PU.1 | Increases | Gfi1, p21, p57, Cdk1, Cdc25a | 23395001, 24573248 |
| Rhob (Ras Homolog Family Member B) | Increases | VWF, Pld3 | 19377048 |
| Sall4 (Spalt like transcription factor 4) | Increases | Epigenetics controlling proteins | 22555391, 22150312 |
| SATB1 (Special AT-rich sequence binding protein 1) | Increases | Sfpi1, Nanog, Numb, Myc | 23563689 |
| SCF (Stem cell factor) | Increases | Dpt, CXCL12, TPO, IL-3, IL-6 | 27365423, 11067877, 25100529 |
| SCL (Stem cell leukemia) | Increases | c-Kit | 19850742, 14726374 |
| SFRP1 (Secreted Frizzled Related Protein 1) | Increases | Ccnd1 and Dkk1, Pparg, Hes1, Runx1 | 19664990 |
| SH2B3 (SH2B adaptor protein 3) | Decreases | TPO/Mpl/JAK2/Lnk | 17284614, 18618018 |
| Sirt1 (Sirtuin 1) | Increases | Trp53, HOXA9 | 23630229 |
| Sirt3 (Mitochondrial sirtuin 3) | Increases | SOD2 | 23375372 |
| Skp2 (S phase kinase-associated protein-2) | Decreases | PTEN, p21, Cdkn1b, Ccnd1, Rbl2, Mad1, p27, p57 | 21502543, 21931116, 15654333, 21885020 |
| Slug or SNAI2 | Decreases | Cyclin D1, p21 | 20032500 |
| SOD (Superoxide dismutase) | Increases | GSH, Catalase | 24605290 |
| STAT5 (Signal transducer and activator of transcription 5) | Increases | Gab2, TPO/c-Mpl, Tie-2, p57 | 20161778, 19258595 |
| Tal1 (T-cell acute lymphocytic leukemia protein 1.) | Increases | SCL, p21, Id1 | 19850742 |
| Tdgf1 (Teratocarcinoma-derived growth factor 1) | Increases | Cripto/GRP78 | 21982233 |
| TNF (Tumor necrosis factor-α) | Decreases | Tnfrsf1a, Tnfrsf1b | 21768269 |
| TPO (Thrombopoietin) | Increases | c-Mpl, p57, Ang-1, c-Myc, Tie2 | 12163458, 18371409, 9892696 |
| Vps72 (Vacuolar protein sorting 72 Homolog) | Increases | Fos, Tcfec, Sfpi1, and Hmgb | 19379700 |
| Vwf (Von willebrand factor) | Increases | Rhob, Pld3 | 19377048 |
| Wilf1 (Wnt inhibitory factor 1) | Decreases | Shh, Jagged-1, Cdh2/N-cadherin, Cxcl12, Bmp4 | 21652676 |