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. 2022 Mar 22;23(5):161. doi: 10.3892/ol.2022.13281

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Copyright: © Jing et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — CMP induced ovarian cancer cell ferroptosis by downregulating Nrf2. SKOV3 and Hey cells were treated with 100 µg/ml CMP for 24 h. RT-PCR analysis showed that CMP reduced (A) Nrf2 and (B) HO-1 mRNA levels but increased the (C) PTGS2 mRNA levels. (D) CMP decreased the expression of Nrf2, HO-1, xCT and GPX4 in SKOV3 and Hey cells. *P<0.05, **P<0.01, ***P<0.001 vs. con. CMP, carboxymethylated pachyman; Nrf2, nuclear factor erythroid 2-related factor 2; HO-1, heme oxygenase-1; PTGS2, prostaglandin-endoperoxide synthase 2; xCT, cystine/glutamate antiporter system X(c)(−); Con, control.