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. 2022 Mar 24;13:867190. doi: 10.3389/fneur.2022.867190

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Copyright © 2022 Rechtman, Brill, Zveik, Uliel, Haham, Bick, Levin and Vaknin-Dembinsky.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Decreased brain volume in MOGAD patients compare to HCs. Brain volume of HCs (n = 22) and MOGAD patients (n = 22) analyzed by Volbrain software. (A) Volume of white matter (512.56 ± 57.33 vs. 458.68 ± 89.60, p = 0.018), gray matter (699.97 ± 59.45 vs. 681.66 ± 106.70, p = 0.476) and total brain (1,214.14 ± 105.65 vs. 1,139.91 ± 135.15, p = 0.048), and volume of (B) cerebellum (134.64 ± 10.28 vs. 124.17 ± 12.42, p = 0.007), (C) brainstem (23.96 ± 2.55 vs. 21.61 ± 2.45, p = 0.003), (D) caudate (7.46 ± 0.79 vs. 6.56 ± 1.03, p = 0.001), (E) thalamus (11.97 ± 0.98 vs. 10.74 ± 1.72, p = 0.008), (F) hippocampus (7.78 ± 0.83 vs. 6.86 ± 1.27, p = 0.011), and (G) amygdala (1.60 ± 0.27 vs. 1.37 ± 0.36, p = 0.024) of MOGAD patients and HCs. MOGAD, Myelin oligodendrocyte glycoprotein antibody disorders; HCs, healthy controls. p * ≤ 0.05, ** ≤ 0.01.