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. 2022 Mar 4;298(4):101803. doi: 10.1016/j.jbc.2022.101803

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Biophysical characterization of HNF-1A R263C and N266S.A, DLS curves for DBD and DD-DBD variants. B, SEC-MALS elution profiles for DBD and DD-DBD variants. Red line: molecular weight based on MALS and refractive index. C, SRCD spectra for DBD and DD-DBD variants. D, SAXS scattering curves for DBD and DD-DBD variants. E, SAXS distance distribution functions for DBD and DD-DBD variants. F, dimensionless Kratky plot for DBD variants, with the cross indicating the expected maximum for a globular particle (√3, 1.104) (61). DBD, DNA-binding domain; DD, dimerization domain; DLS, dynamic light scattering; HNF-1A, hepatocyte nuclear factor 1A; SAXS, small-angle X-ray scattering; SEC-MALS, size-exclusion chromatography–multi-angle light scattering; SRCD, synchrotron radiation circular dichroism.