Figure 6.
MORE and PORE DNA-binding modes of POU transcription factors (29, 30, 31, 32, 33). Transcription factors in MORE arrangement are bound with both POUS and POUH domains on the same side of the DNA molecule. The homeodomains are in close proximity and the linker is compact. In PORE-binding mode, the POUS and POUH domains are located on opposite sides of the DNA, with the linker being extended across the DNA symmetry axis. MORE, More of PORE; PORE, palindromic Oct-factor response element; POUS, Pit-Oct-Unc-specific domain; POUH, Pit-Oct-Unc homeodomain.