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. 2022 Mar 24;13:860362. doi: 10.3389/fphar.2022.860362

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Copyright © 2022 Xu, Li, Lin, Liang, Qin, Ding, Chen and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Iso inhibits the collagen deposition induced by CS. Lung tissues were subjected to Masson staining. (A) Representative histopathological sections of collagen deposition (blue color) in lungs (scale bar 100 μm/50 μm). (B) Quantitative analysis of collagen deposition (n = 5 mice per group). Data was shown as mean (±SD) (B). To test for group differencses one-way ANOVA (B) was applied. ^## p < 0.01, ^### p < 0.001 vs. control group and **p < 0.01, ***p < 0.001 vs. CS group and ⁺ p < 0.05 vs. CS + Iso 30 mg/kg group.