Table 3. The baseline gene mutations in the 7 patients that had NGS results.

Gene mutations	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7
EGFR Exon 19 Deletion	X	X		X	X	X	X
TP53		X	X	X	X	X
RB1 loss		X		X	X	X
CCNE1 EGFR amp		X	X	X
ZNF217		X		X	X
INHBA MCL1 CARD11 IKZF1			X	X
MPL APC MET			X		X
EPHA5 ARID1A EGFR R677C DICER1 CD79A PIK3CA FAS FAT1		X
EGFR L858R SPTA1 GRMJ NKX2-1 DDR2 NFKBIA KRAS BCL2L2 ABL2 SDHC STAG2 FOXP1 RAC1 NTRK1 HGF CDK6 DOT1L SMAD3 PIK3CG MAP2K1 CBFB EGFR L62R CIC MAGI2 BRCA2 CHD2 PMS2 KDM5A ATM MYC			X
ATRX RET AKT2 CEBPA FAM46C DAXX KDM6A				X
IL7R ARID2 BRAF SMO CHEK2 LRP1B ARFRP1 CHD4 PIK3CB RICTOR FGFR1 CREBBP EGFR T790M FGF10					X
FGFR3						X

Patients 2–6 had NGS both at baseline and after transformation. Patients 1 and 7 had NGS after transformation. NGS, next-generation sequencing.