Table 5. The acquired gene mutations in the 5 patients (patient 2–6) that had NGS both at baseline and after transformation.

Acquired gene mutations	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6
WNK1 APC KMT2C ATRX PIAS4 SRP68 TERT LMNA CBLB RNF139 PTPRT MALT1 CFTR CRLF2 AMER1 TOP2A SLC47A2 BCLAF1 ZMYM3 HSP90AA1 EGFR Copy number gain	X
KIT		X
PPARG CD22 BCL6			X
ZRSR2 FOXO1 KDR SMAD4 RANBP2				X
RPTOR ABL2 IRS2 KLHL6 PDGFRB GNAS AURKA PTCH1 SMAD2 FLT3 KDM5A					X

NGS, next-generation sequencing.