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. 2022 Mar 24;12:826617. doi: 10.3389/fonc.2022.826617

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Copyright © 2022 Mijit, Wireman, Armstrong, Gampala, Hassan, Schneeweis, Schneider, Zhang, Fishel and Kelley

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PRDX1 is an effective target enhancing cellular sensitivity to Ref-1 inhibitors in mouse PDAC cells. (A) PRDX1 knockdown efficiency in KC3590 Vector and C13 cell lines were greater than 80% comparing to scrambled control (SCR). Vinculin was used as loading control. (B–D) The cytotoxicity of Ref-1 inhibitors, APX3330, APX2009, APX2014 upon the condition of PRDX1 knockdown both in Vector and C13 were assessed. (E) cytotoxicity of RN7-58 was also evaluated along with Ref-1 inhibitors. Two-way ANOVA, **p < 0.01, ***p < 0.001. At least three independent experiments were performed (N = 3).