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. 2022 Mar 24;12:826617. doi: 10.3389/fonc.2022.826617

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Copyright © 2022 Mijit, Wireman, Armstrong, Gampala, Hassan, Schneeweis, Schneider, Zhang, Fishel and Kelley

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of RelA on cellular redox imbalances caused by Ref-1 inhibitors in PDAC cells. (A–C) intracellular ROS levels were measured upon PRDX1 knockdown cells at 48 hours post-transfection and following 2 hours of Ref-1 inhibitor treatment with APX3330 (75 μM), APX2009 (20 μM), APX2014 (20 μM). These experiments were repeated four times (N=4), and then compared by Two-way ANOVA of *p < 0.05, **p < 0.01, ***P < 0.001, ****p < 0.0001. (D) NADPH/NADPt ratio in PRDX1 knockdown cells (1nM/48h) was assessed following APX2009 treatment (12.5µM/5h). two-way ANOVA, **p < 0.01, ***p < 0.001, N=3.