Table 3.

Association of pre-treatment immune cell infiltration and cells of the tumor microenvironment with response to neoadjuvant chemoradiotherapy.

Cell types	ypT0N0, n (%)			ypT0, n (%)
Total n=16	ypT0N0	Rest	p	ypT0	Rest	p
T-Helper Cells
Low	3 (37)	5 (63)		3 (37)	5 (63)
High	4 (50)	4 (50)	0.614	5 (63)	3 (37)	0.317
Exhausted T-Helper Cells
Low	4 (50)	4 (50)		5 (63)	3 (37)
High	3 (37)	5 (63)	0.614	3 (37)	5 (63)	0.317
Regulatory T-Cells
Low	4 (50)	4 (50)		5 (63)	3 (37)
High	3 (37)	5 (63)	0.614	3 (37)	5 (63)	0.317
Cytotoxic T-Cells
Low	3 (37)	5 (63)		4 (50)	4 (50)
High	4 (50)	4 (50)	0.614	4 (50)	4 (50)	1.000
PD1+ cytotoxic T-Cells
Low	6 (67)	3 (33)		7 (78)	2 (22)
High	1 (14)	6 (86)	0.036	1 (14)	6 (86)	0.012
Macrophages
Low	2 (25)	6 (75)		3 (37)	5 (63)
High	5 (63)	3 (37)	0.131	5 (63)	3 (37)	0.317
PD1+ macrophages
Low	5 (63)	3 (37)		6 (75)	2 (25)
High	2 (25)	6 (75)	0.131	2 (25)	6 (75)	0.046
Cancer-associated fibroblasts
Low	6 (67)	3 (33)		6 (67)	3 (33)
High	1 (14)	6 (86)	0.036	2 (29)	5 (71)	0.131
PD-L1+ Cancer-associated fibroblasts
Low	3 (37)	5 (63)		4 (50)	4 (50)
High	4 (50)	4 (50)	0.614	4 (50)	4 (50)	1.000
Immune Cells
Low	4 (44)	5 (56)		4 (44)	5 (56)
High	3 (43)	4 (57)	0.949	4 (57)	3 (43)	0.614
PD-L1+ Immune Cells
Low	3 (33)	6 (67)		4 (44)	5 (56)
High	5 (57)	3 (43)	0.341	4 (57)	3 (43)	0.614
Proliferating Immune Cells
Low	4 (40)	6 (60)		4 (50)	4 (50)
High	3 (50)	3 (50)	0.696	3 (50)	3 (50)	1.000

P-values according to Pearson chi-squared test.

Bold values indicate p-values <0.05.