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. 2022 Mar 24;13:861670. doi: 10.3389/fimmu.2022.861670

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Copyright © 2022 Gray, Biron-Girard, Wakeley, Chung, Chen, Quiles-Ramirez, Tolbert and Ayala

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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VISTA expression correlates with CD4⁺ T_reg population increase following CLP and VISTA^-/- mice fail to expand the CD4⁺T_reg population in the spleen. (A) Summary graph of VISTA⁺ CD4⁺ T_reg frequency in the spleen. (B) Summary graph of CD4⁺ T_reg frequency in the spleen and (C) representative flow cytometry plots comparing fluorescence minus one (FMO) control, sham (WT), CLP (WT), and CLP (VISTA^-/-) samples. Summary graphs show mean ± SEM [WT-sham: n = 8, WT-CLP: n = 8, VISTA^-/ ^– sham: n = 8, VISTA^-/- -CLP: n = 13]; significance *p < 0.05; **p < 0.01.