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. 2022 Mar 24;13:861670. doi: 10.3389/fimmu.2022.861670

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Copyright © 2022 Gray, Biron-Girard, Wakeley, Chung, Chen, Quiles-Ramirez, Tolbert and Ayala

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of suppressive markers is upregulated on CD4⁺ T_regs and is downregulated on CD4⁺CD8⁺ T_regs in the thymus of VISTA^-/- mice. Median fluorescence intensity (MFI) of (A) Foxp3, (B) CTLA4, (C) CD25, and (D) CD69 on CD4⁺ T_regs in the thymus. Median fluorescence intensity (MFI) of (E) Foxp3, (F) CTLA4, (G) CD25, and (H) CD69 on CD4⁺CD8⁺ T_regs in the thymus. Summary graphs show mean ± SEM [WT-sham: n = 3, WT-CLP: n = 3, VISTA^-/-sham: n = 4, VISTA^-/- -CLP: n = 4]; significance *p < 0.05; **p < 0.01; ***p < 0.001.