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. 2022 Feb 22;14(4):e15344. doi: 10.15252/emmm.202115344

Figure 5. FMRP‐deficiency alleviates atherosclerosis.

Figure 5

  1. Atherosclerosis experiment design in Fmr1+/+ and Fmr1−/− mice that were injected with AAV_PCSK9 and fed WD (16 weeks).
  2. Lesion area calculated from en face aorta, stained with ORO (n = 12–13 mice per group; Scale bar = 5 mm).
  3. Total plaque area was calculated from hematoxylin & eosin (H&E)‐stained aortic root sections (n = 8 mice per group; Scale bar = 300 µm).
  4. Foam cell area was calculated from ORO‐stained aortic root sections (n = 8 mice per group; Scale bar = 300 µm).
  5. Necrotic area was calculated from H&E‐stained aortic root sections (n = 8 mice per group; Scale bar = 100 µm).
  6. Atherosclerosis experiment design in myFmr1+/+ and myFmr1−/− mice that were injected with AAV_PCSK9 and fed WD (16 weeks).
  7. Lesion area calculated from en face aorta, stained with ORO (n = 9 mice per group; Scale bar = 5 mm).
  8. Total plaque area was calculated from H&E‐stained aortic root sections (n = 9–6 mice per group; Scale bar = 300 µm).
  9. Foam cell area was calculated from ORO‐stained aortic root sections (n = 9–6 mice per group; Scale bar = 300 µm).
  10. Necrotic area was calculated from H&E‐stained aortic root sections (n = 9–6 mice per group; Scale bar = 100 µm).

Data information: Data are mean ± SEM; Mann Whitney U test.

Source data are available online for this figure.