Table 2.

Binding affinities of VHH‐B9 for BACE1 and BACE2.

	Binding affinities of VHH‐B9 to BACE1 vs. BACE2
	Conc. (nM)	kon (M−1 s−1)	koff (s−1)	KD (nM)
mBACE1*	100	2.24 × 105	7.20 × 10‐4	3.2
hBACE1*	100	1.53 × 105	4.43 × 10‐4	2.9
mBACE2	100	NR	NR	NR*

h, human; m, mouse; NR, no response.