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. 2022 Mar 24;13:803121. doi: 10.3389/fmicb.2022.803121

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Copyright © 2022 Aguilera, Mascardi, Belforte, Rosso, Quesada, Llovet, Iraola, Trinks and Penas-Steinhardt.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Core microbiome for each group PPG (A) and PG (B). (C) Venn diagram represents shared care genera between groups. Core genera were defined as 0.1% of detection and 50% of prevalence. (D) Volcano plot of the differentially abundant genera between PPG and PG patients. The W-value represents the number of times the null-hypothesis (the average abundance of a given feature in a group is equal to that in the other group) was rejected for a given feature. Red dash lines indicate a significance a priori threshold for differentially abundance set at W ≥ 248 (W > 80% of the total number of genera) and clr (centered logarithmic ratio) > | 2|. Significant genera more abundant in PPG are represented in different colors; whereas non-significant genus are in gray.