Table III.
Univariate and multivariate Cox model of prognostic factors for recurrence-free survival (RFS).
| Univariate | Multivariate | |||
|---|---|---|---|---|
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| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
| Age (continuous) | 1.01 (0.97-1.04) | 0.651 | ||
| Sex (male vs. female) | 2.76 (1.23-6.16) | 0.013 | 2.46 (1.00-6.05) | 0.048 |
| Smoking (former/current vs. never) | 2.26 (1.04-4.89) | 0.038 | 1.14 (0.47-2.78) | 0.758 |
| Cell differentiation (well vs. others) | 1.72 (0.80-3.68) | 0.157 | ||
| Tumor size (>2 cm vs. ≤2 cm) | 2.42 (1.11-5.25) | 0.025 | ||
| Lympho-vascular invasion (no vs. yes) | 1.06 (0.44-2.51) | 0.889 | ||
| Vascular invasion (no vs. yes) | 0.70 (0.24-2.07) | 0.527 | ||
| Pleural invasion (no vs. yes) | 0.97 (0.33-2.78) | 0.956 | ||
| Pathologic stage (IB vs. IA) | 2.69 (1.34-5.39) | 0.005 | 1.89 (0.88-4.05) | 0.099 |
| CD155 expression (positive vs. negative) | 3.44 (1.67-7.09) | <0.001 | ||
| PD-L1 (positive vs. negative) | 2.92 (1.28-6.64) | 0.011 | ||
| CD155 expression and PD-L1 expression (CD155+/PD-L1+ vs. others) | 4.41 (1.8-10.30) | <0.001 | 3.20 (1.24-8.22) | 0.016 |
| Mode of lung resection (sub-lobar resection vs. lobectomy) | 0.78 (0.18-3.32) | 0.741 | ||
| Adjuvant chemotherapy (not performed vs. performed) | 1.36 (0.41-4.47) | 0.612 | ||
95% CI, 95% confidence interval; CD155+, CD155 expression-positive; HR, hazard ratio; PD-L1, programmed death-ligand 1; PD-L1+, PD-L1 expression-positive.