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. 2022 Apr 7;19:83. doi: 10.1186/s12974-022-02447-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — scRNA-seq analysis. A Workflow and data table of our scRNA-seq analysis. Aged mice were subjected to 6-h ttMCAO or sham. Three days later, both (sham) or ipsilesional (stroke) hemispheres were collected for scRNA-seq analysis. B Dot plot showing the scaled expression of selected signature genes for each cluster. Dot size depicts the percentage of cells within the cluster expressing each gene, and color intensity indicates the average expression level. C UMAP plot of aggregated data from both groups. D Volcano plot of differentially expressed genes (DEGs) between stroke and sham (Additional file 1: Table S4)