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Effect of general anesthesia on aged App-KI mice in a tail suspension test. Mean (+ SEM) limbs clasping score (A), immobile duration (B) and latency to first immobile episode (C) in each group, WT-Air (n = 7), WT-Des (n = 8), WT-Sev (n = 6), App-Air (n = 13), App-Des (n = 11), and App-Sev (n = 11) group, are shown. **p < 0.010, †p < 0.010 compare to corresponding anesthesia-treated App-KI group
