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. 2022 Apr 7;41:129. doi: 10.1186/s13046-022-02315-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — STC1 promotes metastasis and lipid metabolism in vitro. A WB results of the STC1 expression levels in different OC cell lines. B STC1-knockdown cell lines were established with Skov3-ip1 and Hey cells, and the transfection efficiency was confirmed by WB assays. C PCA of data from untargeted relative quantitative lipidomic analysis. D Volcano plot of individual lipid species significantly up- or down- regulated in the NC group versus the STC1-sh1 and STC1-sh2 groups in Hey cell lines (lipids with a P value < 0.05 and a fold change (FC) > 1.5 or < 0.67 were indicated in blue or red, respectively). E Correlation analysis of the ten lipid classes. F A heat map of significant differences in the variables among the NC, STC1-sh1 and STC1-sh2 groups of Hey cells. The variables were ranked by ANOVA. G TEM images of OC cells in Skov3-ip1 and Hey cell lines (red arrow: mitochondria). H ORO staining of OC cells in Skov3-ip1 and Hey cell lines (red arrow: TGs). (Data are shown as the mean ± SD values. Significance was calculated using Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.)