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. 2022 Apr 7;41:129. doi: 10.1186/s13046-022-02315-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — STC1 promotes metastasis, lipid metabolism and DDP chemoresistance in vivo. A The model of cell injection into nude mice. B-C Luciferase expression was detected in the mouse model. The NC group showed significantly higher flux than the NC + DDP group, STC1-sh1 group and STC1-sh1 + DDP group. D The NC group showed significantly larger tumors than the NC + DDP group, STC1-sh1 group and STC1-sh1 + DDP group. E The tumor weights and tumor volumes in the four groups. F-G The NC groups had metastatic tissues in the liver, spleen and intestine. H H&E staining of metastatic tissues (liver, spleen and intestine) in the NC groups. I Representative WB results of UCP1, TOM20 and perilipin1 in tissues from two mouse tumors generated by injection of the two cell lines. J IF analysis showed the relationship between STC1 and UCP1 in tissues from two mouse tumors generated by injection of the cell lines. (Data are shown as the mean ± SD values. Significance was calculated using Student’s t test. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.)