TABLE 2.
Pathological features in radical prostatectomy specimen
| Zonal location | Whole cohort | TZ cancer | PZ cancer | ND and CZ cancer | P‐value* |
|---|---|---|---|---|---|
| Case number (%) | 270 (100) | 93 (34.4) | 159 (58.9) | 18 (6.7) | N/A |
| Prostate volume (cm3) | 185.40 (143.86‐231.59) | 172.95 (134.52‐240.21) | 187.93 (147.69‐228.32) | 181.16 (156.09‐257.92) | .3802 |
| Tumor volume (cm3) | 2.70 (0.99‐5.89) | 2.56 (1.21‐5.02) | 2.76 (0.81‐5.89) | 7.17 (2.48‐14.97) | .593 |
| Grade group | |||||
| Grade Group 1 (%) | 39 (14.4) | 22 (23.7) | 14 (8.8) | 3 (16.7) | .0011 |
| Grade Group 2 (%) | 126 (46.7) | 49 (52.7) | 71 (44.7) | 6 (33.3) | |
| Grade Group 3 (%) | 48 (17.8) | 11 (11.8) | 34 (21.4) | 3 (16.7) | |
| Grade Group 4 (%) | 10 (3.7) | 2 (2.2) | 6 (3.8) | 2 (11.1) | |
| Grade Group 5 (%) | 47 (17.4) | 9 (9.7) | 34 (21.4) | 4 (22.2) | |
| Extraprostatic extension (EPE) | |||||
| EPE0 (%) | 112 (41.5) | 48 (51.6) | 60 (37.7) | 4 (22.2) | .004 |
| EPE1 (%) | 123 (45.6) | 29 (31.2) | 83 (52.2) | 11 (61.1) | |
| EPEx (%) a | 35 (13.0) | 16 (17.2) | 16 (10.1) | 3 (16.7) | |
| Pathological T stage | |||||
| pT2 (%) | 147 (54.4) | 64 (68.8) | 76 (47.8) | 7 (38.9) | <.0001 |
| pT3a (%) | 83 (30.7) | 29 (31.2) | 48 (30.2) | 6 (33.3) | |
| pT3b (%) | 40 (14.8) | 0 (0) | 35 (22.0) | 5 (27.8) | |
| Positive surgical margin (%) | 96/270 (35.6) | 29/93 (31.2) | 54/159 (34) | 5/18 (72.2) | .679 |
| Intraductal carcinoma (%) | 92/270 (34.1) | 10/93 (10.8) | 71/159 (44.7) | 11/18 (61.1) | <.0001 |
| Lymph node metastasis (pN) | |||||
| pN0 (%) | 232 (85.9) | 85 (91.4) | 134 (84.3) | 13 (72.2) | .186 |
| pN1 (%) | 21 (7.8) | 3 (3.2) | 14 (8.8) | 4 (22.2) | |
| pNx (%) | 17 (6.3) | 8 (5.4) | 11 (6.9) | 1 (5.6) | |
| ERG overexpression (%) | 40 (14.8) | 3/93 (3.2) | 32/159 (20.1) | 5/18 (27.8) | .0001 |
| PTEN‐loss (%) | 35 (13.0) | 2/93 (2.2) | 29/159 (18.2) | 4/18 (22.2) | <.0001 |
| SPINK1 expression (%) | 42 (15.6) | 15/93 (16.1) | 24/159 (15.1) | 3/18 (16.7) | .858 |
| Subgroup by the combination of ERG and SPINK1 expression | |||||
| ERG‐/SPINK1− (%) | 188 (69.6) | 75 (80.6) | 103 (64.8) | 10 (55.6) | .0003 |
| ERG‐/SPINK+ (%) | 42 (15.6) | 15 (16.1) | 24 (15.1) | 3 (16.7) | |
| ERG+/SPINK− (%) | 40 (14.8) | 3 (3.2) | 32 (20.1) | 5 (27.8) | |
Continuous variables are shown in median value and interquartile range.
a
EPEx means indeterminate EPE status because of surgical incision into intraglandular cancer.
*
P‐values are calculated by comparison of TZ and PZ cancer.