TABLE 4.
Cox regression analysis for BCR; comparison of postoperative pathological features and tumor location
| Univariate | Multivariate | |||
|---|---|---|---|---|
| HR (95% CI) | P‐value | HR (95% CI) | P‐value | |
| Tumor volume a | 1.105 (1.075‐1.137) | <.0001 | 1.027 (0.983‐1.073) | .2323 |
| Grade Group (vs GG1/2) | ||||
| Grade group 3‐5 | 4.708 (3.08‐7.196) | <.0001 | 3.593 (2.089‐6.181) | <.0001 |
| pT (vs pT2) pT3 | 3.91 (2.527‐6.051) | <.0001 | 1.649 (0.924‐2.944) | .0908 |
| Positive surgical margin | 2.598 (1.741‐3.875) | <.0001 | 1.794 (1.113‐2.890) | .0164 |
| Lymph node metastasis (vs pN0/x) pN1 | 9.395 (5.527‐15.97) | <.0001 | 3.780 (1.881‐7.598) | .0002 |
| Intraductal carcinoma | 4.87 (3.217‐7.372) | <.0001 | 1.288 (0.704‐2.357) | .4118 |
| PTEN‐loss | 2.208 (1.335‐3.655) | .0021 | 1.496 (0.807‐2.770) | .2006 |
| Subgroup by the combination of ERG and SPINK1 overexpression (vs ERG‐/SPINK1‐) | ||||
| ERG‐/SPINK1+ | 1.074 (0.622‐1.855) | .7969 | ||
| ERG+/SPINK− | 1.080 (0.616‐1.893) | .7882 | ||
| PZ tumor location (vs TZCa) | 3.471 (1.985‐6.068) | <.0001 | 2.241 (1.214‐4.136) | .0099 |
a
HR shows risk by a tumor volume increase of 1 cm3.