Figure 23.

Model of α-Syn hexamer channel compared to the structure of Aerolysin [32]. (a) Schematic of the hexamer channel. (b & c) Side and top views of Cryo EM channel structure of Aerolysin. (d) AFM images of a small α-Syn channel (adapted from Quist et al. [21]) and Aerolysin (Adapted with permission from He J, Wang J, Hu J, et al. [67]). The diameters of the ovals and circles are 6.8, 4.8, and 1.3 nm as predicted for the outer walls and pore of the α-Syn hexamer channel and 7.4, 5.5, and 1.7 nm as calculated for the Aerolysin heptamer.