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. 2022 Mar 24;13:737536. doi: 10.3389/fimmu.2022.737536

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Copyright © 2022 Ray, Jeong, Kwon, Kim and Moon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of STR exposure on CDDP-induced renal injury. Eight-week-old wild type male mice (n = 3–5) were orally pre-exposed to the vehicle or streptomycin (20 mg/mouse) for 24 h and then renal injury was induced with CDDP (20 mg/kg) via intraperitoneal administration for an additional 72 h. (A) Periodic acid-Schiff (PAS) staining. (B) Tubular dilation levels according to PAS staining. (C, D) levels of blood urea nitrogen (BUN, C) and creatinine (D). (E) The mRNA expression was measured in the mouse kidney using real-time RT-PCR. Results are representative of three independent experiments. The results are shown as a box plot with Tukey whiskers and the different letters (a–c) over each box represent significant differences between groups using ANOVA with Newman–Keuls method as a post hoc ANOVA assessment (p < 0.05).