FIGURE 4.

The Lactamome: Radial chemogram of major β-lactams by chemical similarity. Clustering used hierarchical complete linkage MAACS-keyed Tanimoto coefficient. Clustering was performed using ChemMine and visualized using Dendroscope (Huson et al., 2007; Backman et al., 2011). Colors indicate major chemotypes. Note that the oxacephems: moxalactam and flomoxef, are colored purple. Bolded lactams marked with an asterisk indicate drugs with high allergy potential (>10%) relating to the R₁ benzyl groups.