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. 2022 Mar 24;13:807955. doi: 10.3389/fmicb.2022.807955

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Copyright © 2022 Turner, Muraoka, Bedenbaugh, Childress, Pernot, Wiencek and Peterson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lactamomes depicting (A) chemotype, (B) compound generation, and (C) h-Woodward values. (A) The chemotype is a reproduction of Figure 4 to aid comparisons to the other figures. (B) The generational lactamome assigns generation levels (1st–5th) to individual drugs based on how they most currently referenced in literature. Individual drugs that do not conform to generational naming are colored in black. (C) h-Woodward lactamome is colored using a heatmap with higher h-Woodward values in green and lower h-Woodward values in red. Bolded lactams marked with an asterisk indicate drugs with high allergy (>10%) relating to the R₁ benzyl groups.