Table 5.

Thiopurine-induced pancreatitis in leading Crohn’s disease guideline publications

Guideline	Reference to pancreatitis	Quantification of thiopurine-association pancreatitis risk
British Society of Gastroenterology consensus guidelines21 Published June 2019	Recognises that thiopurines are contraindicated in pancreatitis, even at a low dose, due to high chances for recurrence. Does not state risk of occurrence on thiopurines.	No effect size estimate provided.
National Institute for Health and Care Excellence—NG12922 Published May 2019	Recognises that thiopurines are contraindicated if a patient has experienced past episodes of pancreatitis. Does not state risk of occurrence on thiopurines.	No effect size estimate provided.
American College of Gastroenterology clinical guideline23 Published April 2018	Recognises that thiopurines are associated with pancreatitis.	No effect size estimate provided.
Japanese Society of Gastroenterology clinical practice guidelines24 Published February 2018	Recognised pancreatitis as a side effect of azathioprine and 6-mercaptopurine (evidence level: A)	No effect size estimate provided.
European Crohn’s and Colitis Organisation consensus guideline25 26 Published September 2016	Recognises that thiopurines are contraindicated if a patient has previous experienced episodes of pancreatitis. Does not state risk of occurrence on thiopurines.	No effect size estimate provided.
World Gastroenterology Organisation global guidelines27 Published August 2015	No reference.	No effect size estimate provided.
American Gastroenterological Association Institute guideline28 Published December 2013	No reference.	No effect size estimate provided.