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. Author manuscript; available in PMC: 2022 Apr 7.
Published in final edited form as: J Med Chem. 2022 Jan 4;65(3):2388–2408. doi: 10.1021/acs.jmedchem.1c01851

Table 3.

Residual Activity Rates of Series III Compounds on Poly(I:C)-Induced Expression of Inflammatory Genes CIG5 and IL-6 in hSAECsa

graphic file with name nihms-1792046-t0042.jpg
Compd R1 CIG5 (%) IL-6 (%)
11 OMe 2.19 ± 0.16 3.42 ± 0.30
42 NH2 22.6 ± 1.55 12.7 ± 1.01
45 graphic file with name nihms-1792046-t0043.jpg 0.62 ± 0.005 13.7 ± 1.06
46 graphic file with name nihms-1792046-t0044.jpg 4.58 ± 0.33 23.7 ± 2.15
47 graphic file with name nihms-1792046-t0045.jpg 5.47 ± 0.41 6.63 ± 0.48
48 graphic file with name nihms-1792046-t0046.jpg 1.12 ± 0.09 32.8 ± 2.84
49 -OH 214 ± 17.1 25.3 ± 2.13
50 -OH 0.39 ± 0.03 1.71 ± 0.13
51 -OTs 0.63 ± 0.05 6.98 ± 0.63
52 graphic file with name nihms-1792046-t0047.jpg 0.34 ± 0.025 0.35 ± 0.03
53 graphic file with name nihms-1792046-t0048.jpg 0.21 ± 0.02 0.40 ± 0.03
a

Residual activity rates (%) of tested compounds (at the final concentration of 10 μM) comparing to the positive control group (poly(I:C) alone, at 100%) are presented as the average from three independent measurements (mean ± SD, n = 3).