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. Author manuscript; available in PMC: 2022 Apr 7.
Published in final edited form as: J Med Chem. 2022 Jan 4;65(3):2388–2408. doi: 10.1021/acs.jmedchem.1c01851

Table 4.

IC50 Values of Selected Compounds against Poly(I:C)-Induced Expression of Inflammatory Genes CIG5 and IL-6 in hSAECsa

compd CIG5 (μM) IL-6 (μM)
1 1.73 ± 0.19 3.49 ± 0.38
3 0.97 ± 0.11 1.06 ± 0.09
11 1.35 ± 0.17 1.83 ± 0.19
45 2.06 ± 0.24 1.88 ± 0.21
50 0.86 ± 0.12 2.29 ± 0.27
51 10.8 ± 1.24 4.31 ± 0.53
52 0.20 ± 0.03 0.37 ± 0.07
53 0.39 ± 0.05 0.22 ± 0.04
a

IC50 values are reported as the mean ± SD derived from three independent measurements. Each one is determined from 8 different concentrations, and IC50 values are calculated using Four Parameters Regression method (https://www.aatbio.com/tools/ic50-calculator/).