Table 3.
Absorption | Distribution | Metabolism | Excretion | Toxicity | |||
---|---|---|---|---|---|---|---|
GI absorption | Skin Permeability (log Kp) | BBB/CNS permeability | CYP2D6 substrate/inhibitor | Clearance (log ml/min/kg) | Renal OCT2 substrate | AMES | Hepatotoxicity |
Low | − 2.73 | No | No | 0.25 | No | No | No |