Figure 3.

Associations between asthma and airway androgen receptor (AR) expression exist except in postmenopausal women and prepubescent children. Box-and-whisker plots of normalized AR expression from bronchial epithelia in A, adults, and nasal epithelia in B, children, broken down by age and sex in adults and by age in children. Center lines indicate median values, boxes indicate first quartile to third quartile range, whiskers indicate values up to 1.5 times interquartile range, and points indicate outlying values. For visual clarity, one outlier each below 0.7 normalized expression (in female ages 18-50 asthma) and above 1.3 (in female ages 18-50 control) were excluded from plot. Sample sizes for each group: A, male age < 51 asthma 94, control 71; male ≥ 51 asthma 17, control 4; female < 51 asthma 130, control 59; female ≥ 51 asthma 23, control 12. B, age < 11 asthma 20, control 21; age ≥ 11 asthma 29, control 37. P values from 2-tailed t tests of asthma vs control within each sample group are shown.