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. 2022 Mar 24;10:875363. doi: 10.3389/fbioe.2022.875363

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Copyright © 2022 Chai, Huang, Mahmut, Wang, Yao, Zhang, Zhuang, Xie, Xu and Jiang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bioactive scaffold promoted osteogenic differentiation of BMSCs in vitro. The mRNA expression levels of COL1 and ALP of BMSCs in bioactive scaffolds (A). The alizarin red staining of BMSCs in bioactive scaffolds (B) (bar = 200 μm). Quantitative statistics of mineralization in bioactive scaffolds (C). The mRNA expression levels of COL1 and ALP of BMSCs co-cultured with bioactive scaffolds (D) The alizarin red staining of BMSCs co-cultured with bioactive scaffolds (E). Quantitative statistics of mineralization in BMSCs co-cultured with bioactive scaffolds (F).