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. 2022 Mar 24;3:840328. doi: 10.3389/fpain.2022.840328

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Copyright © 2022 Zhang and Furst.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Results from tract-based analyses based on DTI of pain studies: FA significantly reduced in patients; FA significantly increased in patients; FA was not significantly different; Reduced FA signficantly correlated with increased pain intensity/sensitivity; Increased FA significantly correlated with greater analgesic response; Not analyzed. [a] Cortical and subcortical areas of major fiber tracts (specific tracts included); [b] Some areas in the brainstem without specific definition of tracts. [c] Significant findings are presented based on RD instead of FA which showed a weaker significance. TMD, temporomandibular disorder; HC, healthy control; CH, cluster headache; MTBI, mild traumatic brain injury; IBS, irritable bowel syndrome; IC/BPS, interstitial cystitis/bladder pain syndrome; CS, cervical spondylosis with pain; CMP, chronic musculoskeletal pain; LBP, low back pain; CPSP, central post-stroke pain; TBSS, tract-based spatial statistics; SPM, statistical parametric mapping; CST, corticospinal tract; STT, spinothalamic tract; ATR, anterior thalamic radiation; FPT, frontopontine tract; MFT, medial forebrain tract; PTR, posterior thalamic radiation; ALIC, anterior limb of internal capsule; PLIC, posterior limb of internal capsule; EC, external capsule; SCP, superior cerebellar peduncle; DLF, dorsal longitudinal fasciculus; MLF, medial longitudinal fasciculus; MCP, middle cerebellar peduncle; ICP, inferior cerebellar peduncle.

Inline graphic — Results from tract-based analyses based on DTI of pain studies: FA significantly reduced in patients; FA significantly increased in patients; FA was not significantly different; Reduced FA signficantly correlated with increased pain intensity/sensitivity; Increased FA significantly correlated with greater analgesic response; Not analyzed. [a] Cortical and subcortical areas of major fiber tracts (specific tracts included); [b] Some areas in the brainstem without specific definition of tracts. [c] Significant findings are presented based on RD instead of FA which showed a weaker significance. TMD, temporomandibular disorder; HC, healthy control; CH, cluster headache; MTBI, mild traumatic brain injury; IBS, irritable bowel syndrome; IC/BPS, interstitial cystitis/bladder pain syndrome; CS, cervical spondylosis with pain; CMP, chronic musculoskeletal pain; LBP, low back pain; CPSP, central post-stroke pain; TBSS, tract-based spatial statistics; SPM, statistical parametric mapping; CST, corticospinal tract; STT, spinothalamic tract; ATR, anterior thalamic radiation; FPT, frontopontine tract; MFT, medial forebrain tract; PTR, posterior thalamic radiation; ALIC, anterior limb of internal capsule; PLIC, posterior limb of internal capsule; EC, external capsule; SCP, superior cerebellar peduncle; DLF, dorsal longitudinal fasciculus; MLF, medial longitudinal fasciculus; MCP, middle cerebellar peduncle; ICP, inferior cerebellar peduncle.