Table 1. Frequency of immune responses to the S and N+M peptide pools in asymptomatic and symptomatic participants.
| A | ||||
| IFN-γ | Asymptomatic (n = 124) | Symptomatic (n = 105) | All participants (n = 229) | P-value |
| S Pool | 43 (34.7%) | 26 (24.8%) | 69 (30.1%) | 0.10 |
| N+M pool | 49 (39.5%) | 36 (34.3%) | 85 (37.1%) | 0.41 |
| IL2 | ||||
| S Pool | 19 (15.3%) | 7 (6.7%) | 26 (11.4) | 0.04 |
| N+M pool | 13 (10.5%) | 10 (9.5%) | 23 (10.0) | 0.81 |
Panel A: Comparison of the numbers and percent of asymptomatic and symptomatic participants with positive IFN-γ or IL2 responses post-infection to the S pool or the N+M pool. The frequency of IFN-γ responses to the S and N+M pool were higher in asymptomatic than symptomatic participants, although the differences were not statistically different between asymptomatic and symptomatic participants. However, the frequency of IL2 responses to the S pool was significantly higher among asymptomatic than symptomatic participants (p = 0.04). The frequency of IL2 responses to the N+M pool were higher in asymptomatic than in symptomatic participants, although the difference was not statistically different.
Panel B: The numbers of IFN-γ or IL2 responses of all participants (asymptomatic and symptomatic) to the S and N+M peptide pools were compared using McNemar’s Chi-Square. IFN-γ responses to the N+M pool among all infected participants were more frequent (37.1%) than IFN-γ responses to the S pool (30.1%) (p = 0.03), but not IL2 responses (p = 0.5).