Table 2. Combination of atrial fibrillation and chronic kidney disease and risk of bleeding, ischemic stroke and mortality.

Atrial fibrillation	Chronic kidney disease		Number of events	IR	Crude HR (95%CI)	*Adjusted HR (95%CI)
BLEEDING
No	No	N = 9,268	211	2.6	1 (ref)	1 (ref)
Yes	No	N = 374	18	7.7	2.7 (1.7–4.4)	1.9 (1.1–3.2)
No	Yes	N = 2,427	116	5.7	2.1 (1.7–2.7)	1.5 (1.2–1.9)
Yes	Yes	N = 325	37	17.2	6.1 (4.3–8.7)	3.0 (2.0–4.4)
ISCHEMIC STROKE
No	No	N = 9,268	233	2.9	1 (ref)	1 (ref)
Yes	No	N = 374	19	8.0	2.7 (1.7–4.4)	1.8 (1.1–3.1)
No	Yes	N = 2,427	123	6.1	2.1 (1.7–2.6)	1.5 (1.2–1.9)
Yes	Yes	N = 325	46	21.3	7.3 (5.3–10.0)	4.2 (3.0–6.0)
MORTALITY
No	No	N = 9,268	1,189	14.5	1 (ref)	1 (ref)
Yes	No	N = 374	75	30.7	2.5 (2.0–3.1)	1.4 (1.1–1.8)
No	Yes	N = 2,427	747	35.8	2.6 (2.4–2.8)	1.5 (1.3–1.6)
Yes	Yes	N = 325	192	81.7	6.5 (5.6–7.6)	2.2 (1.9–2.6)

Abbreviations: IR, incidence rate per 1000 person-years; HR, hazard ratio; CI, confidence interval.

Notes:

*Adjusted: Hazard ratio adjusted for age, sex, body mass index, hypertension, stroke, myocardial infarction, peripheral arterial disease, heart failure, diabetes mellitus, use of anticoagulant drugs (vitamin K antagonists and direct oral anticoagulants), antiplatelet agents and hemoglobin levels.