Figure 1.

Study design. Abbreviations: 5/28 d, days 1–5 of every 28-day cycle; meth, methylated; MGMT, O⁶-methylguanine-DNA methyltransferase; Q2W, every 2 weeks; RT, radiotherapy; TMZ, temozolomide; unk, unknown; unmeth, unmethylated. ^aPatients in both cohorts had surgical resection prior to starting study treatment. ^bStandard RT (60 Gy; 2-Gy fractions 5 days per week for ≤7 weeks) was administered starting ≥7 days after the first dose of nivolumab.