Table 2.

PICRUSt shows the predicted relative abundance of all KEGG signaling pathways in fecal microbes (Level 3 Kos, > 1%).

KEGG	Spring	Summer	Autumn	Winter	P-value
Metabolic pathways	18.30 ± 0.1a	18.27 ± 0.11ab	18.21 ± 0.12c	18.25 ± 0.09b	<0.001
Biosynthesis of secondary metabolites	9.19 ± 0.04b	9.18 ± 0.04c	9.21 ± 0.04a	9.18 ± 0.06c	0.001
Biosynthesis of amino acids	4.42 ± 0.06b	4.43 ± 0.06b	4.42 ± 0.08b	4.45 ± 0.11a	0.015
Microbial metabolism in diverse environments	4.32 ± 0.03b	4.33 ± 0.02b	4.34 ± 0.02a	4.33 ± 0.09b	<0.001
Carbon metabolism	2.86 ± 0.03b	2.87 ± 0.03b	2.91 ± 0.03a	2.86 ± 0.03b	<0.001
Ribosome	2.52 ± 0.04b	2.52 ± 0.03b	2.57 ± 0.03a	2.52 ± 0.08b	<0.001
ABC transporters	2.01 ± 0.11a	2.04 ± 0.14a	1.86 ± 0.13b	2.06 ± 0.12a	<0.001
Purine metabolism	1.59 ± 0.01a	1.59 ± 0.02a	1.57 ± 0.02b	1.58 ± 0.02a	<0.001
Two-component system	1.56 ± 0.06b	1.58 ± 0.06ab	1.58 ± 0.07a	1.59 ± 0.06a	0.028
Quorum sensing	1.35 ± 0.05b	1.36 ± 0.05b	1.35 ± 0.07b	1.38 ± 0.04a	0.035
Pyrimidine metabolism	1.26 ± 0.01	1.26 ± 0.01	1.25 ± 0.01	1.25 ± 0.02	0.166
Aminoacyl-tRNA biosynthesis	1.15 ± 0.02b	1.15 ± 0.02b	1.16 ± 0.02a	1.15 ± 0.03b	<0.001
Glycolysis / Gluconeogenesis	1.14 ± 0.01a	1.14 ± 0.01a	1.13 ± 0.01b	1.13 ± 0.01a	<0.001
Cysteine and methionine metabolism	1.10 ± 0.02c	1.10 ± 0.02c	1.12 ± 0.02a	1.10 ± 0.03b	<0.001
Amino sugar and nucleotide sugar metabolism	1.10 ± 0.02a	1.10 ± 0.02a	1.06 ± 0.02b	1.10 ± 0.02a	<0.001
Pyruvate metabolism	1.06 ± 0.02b	1.06 ± 0.02b	1.10 ± 0.02a	1.07 ± 0.02b	<0.001
Oxidative phosphorylation	1.07 ± 0.03b	1.07 ± 0.02b	1.08 ± 0.04a	1.06 ± 0.03b	0.001
Carbon fixation pathways in prokaryotes	1.01 ± 0.03b	1.01 ± 0.03b	1.04 ± 0.02a	1.00 ± 0.03b	<0.001
Glycine, serine and threonine metabolism	1.00 ± 0.01b	1.00 ± 0.01b	1.01 ± 0.01a	1.00 ± 0.01b	<0.001

The value shown are the mean ± SD. Different letters (a, b, c) in the same line indicate significant differences (P <0.05, Metastats).